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KMID : 0377220120370040250
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Medical Journal of Chosun Univercity
2012 Volume.37 No. 4 p.250 ~ p.255
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Relationship of Hemoglobin A1c with Cardiovascular Disease Risk Factor in Non-Diabetic Elderly Populations
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Kang Ji-In
Jung Jae-Sik
So Jung-Hae
Choi Young-Min
Kim Jin-Hwa
Kim Sang-Yong
Bae Hak-Yeon
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Abstract
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Glycosylated hemoglobin (HbA1c) is a useful index of mean blood glucose concentration over the preceding 2 to 3 months. Elevated HbA1C is associated with a higher incidence of microvascular and macrovascular complications in patient with diabetes mellitus. The aim of this study is to estimate the association of HbA1c with cardiovascular risk factor, especially in non-diabetic elderly population. After individuals previously diagnosed with diabetes, hypertension or dyslipidemia and those treated with hypoglycemic agent, antihypertensive agent, and lipid lowering agent were excluded, 370 adult (177 males and 193 females) aged over 60 years were included as the subject. HbA1c revealed a significant correlation with fasting plasma glucose, triglyceride, LDL cholesterol, and HDL cholesterol. According to analysis by sex, HbA1c revealed a significant correlation with fasting plasma glucose and LDL cholesterol in male, but with fasting plasma glucose and triglyceride in female. Multiple regression analysis showed that HbA1c had a positive association with triglyceride, LDL cholesterol, and a negative association with HDL cholesterol. These results demonstrated that the HbA1c level is correlated with cardiovascular risk factor in non-diabetic elderly population, and thus we suggest that HbA1c may predict cardiovascular risk as a useful tool in non-diabetic elderly population.
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KEYWORD
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HbAlc, Cardiovascular risk factor, Non diabetic elderly population
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